Aesthetic Medicine · Face
Polynucleotides
Regenerates thin, tired or irritated skin by stimulating its natural capacity to repair itself. Both PDRN and PN are available at the clinic. Particularly suited to the eye area, with a result that builds over six to eight weeks.
The treatment
What is
Polynucleotides?
Polynucleotides are short fragments of purified DNA, extracted from salmon or trout milt and highly filtered. This origin often surprises patients, so let us say it plainly: the product is purified to the point where no functional genetic material remains, and it has been used in medicine for decades, notably for wound healing.
Two families exist, and the Petit-Lancy clinic holds both. They come from the same raw material and differ in the length of their chains. Reviews published in 2025 place the boundary at around 1500 kilodaltons: below it the material is called PDRN, above it PN.
PDRN, the shorter form, works mainly through signalling. It activates the adenosine A2A receptor, which reduces inflammation and restarts collagen production by the fibroblasts. It is preferred on damaged skin, acne scarring and pigment marks.
PN, the longer form, works mainly through its structure. It binds water and acts as a scaffold for the supporting matrix of the dermis. It is preferred for skin quality in the broad sense, for hydration and for prevention.
In both cases the product does not fill and does not merely hydrate. The skin gradually regains thickness, suppleness and a better blood supply. This is why these treatments are particularly valued around the eyes, an area where the skin is very thin, where fillers puff up easily and where few treatments genuinely suit. They also give good results on thin, sensitive or reactive skin, on the neck, and alongside skin damaged by sun or acne.
The usual protocol comprises two to three sessions two to four weeks apart. The result builds over six to eight weeks, then holds for six to nine months depending on the area and your skin.
One honest reservation: this is a recent treatment in aesthetic medicine. Clinical results are encouraging, but with less long-term experience behind them than hyaluronic acid or botulinum toxin, and most of the published research concerns PDRN.
The choice between PDRN and PN, or a combination of the two, is made at consultation according to the state of your skin. The physician will explain where the treatment fits in your overall plan.
Why choose this treatment
- Both PDRN and PN available: the physician picks the chain length that suits your skin
- One of the few treatments suited to the eye area with no risk of puffiness
- Calming effect: suitable for sensitive, reactive or irritated skin
- Gradually thickens skin that has become too thin
- Adds no volume: your features are not changed
- Also useful on the neck, décolleté and acne-scarred skin
- Short session, with no recovery time
- Combines with botulinum toxin and hyaluronic acid
How it works
The treatment
process.
Prior consultation
You must report any allergy to fish or shellfish: the product is of marine origin. Also report any pregnancy, breastfeeding or autoimmune condition. Avoid alcohol and anti-inflammatories for 48 hours. Come without make-up, with the eye area free of cosmetics. We postpone in case of skin infection or an active cold sore on the area.
Application of the treatment
After disinfection, the physician places the product through small superficial injections spread across the area. Under the eyes, the points are few and placed with care, as the skin there is very thin. You feel brief pinpricks. Small bumps appear at each point: they are expected and settle within a few hours.
Post-Procedure Care & Follow-Up
Redness, small bumps and sometimes slight bruising last from a few hours to two days. Do not massage the area. Avoid strenuous exercise, saunas, steam rooms and sun for 48 hours. Make-up is fine from the next day. The next session is scheduled two to four weeks later: it is the repetition that builds the result.
Pricing
Detailed pricing
Note: the initial consultation (CHF 100.-) is waived if treated the same day, or deducted from a signed quotation (valid 3 months).
- 1 session CHF 500
- Course of 2 sessions CHF 900
- Course of 3 sessions CHF 1 400
Where to get treated
Clinics offering
this treatment.
Frequently asked questions
What you'd like
to know before your session.
Go further
Related
treatments.
Polynucleotides · Aesthetic Medicine · Face
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Polynucleotides?
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